Dupont Chromaclear 7600s and 7776s used to be my main clears. They were great; however, I recently switched to a high solids PPG Omni MC161 and I haven’t looked back. Not only is the Omni cheaper, but it is more clear and builds better thickness. The only drawback is the 12-16 hour time to polish; whereas the Dupont was only 2 hours.
As for safety, technically resiprators aren’t good enough. Isocyanates will pass though skin and worn (old) respirator cartridges.