I looked into using 2K paints for some motorcycle bodywork I’m making, and what I found was that there is a lot of misinformation out there. First up - there is no scientific data showing that isocyanates cause cancer. This seemed to be one of the biggest concerns that people have. But the fact is that anyone saying ISO’s cause cancer is making a false statement.
What ISO’s do cause is asthma-like symptoms. This has been stated by various government organisations and you can also find this in various safety studies, etc.
The reason I mention this is that you have to keep it all in context… Of course you shouldn’t spray 2K without a respirator. But the same is true for ANY kind of painting (like herman mentioned). Also welding, composites work, sanding etc. An appropriate respirator should be used for all those circumstances. There’s nothing special about 2K paint, the same precautions should be taken in many other types of work as well.
Now that those myths and facts are cleared up…
You can get ISO-certified half face masks from Gerson. (Gerson 2K disposable respirator £14.99 and I have this bookmarked for some reason, you may be able to lookup the specs directly from Gerson: http://www.gersonco.com/Products/8211P-Disposable-Dual-Cartridge-Respirator-OVP95---Medium----0871501B__0871501B.aspx ) This is the only manufacturer that seems to specifically mention that their masks can be used with ISO. The strange thing is, they use exactly the same filters, same specs etc. as all the other brands. So what gives? Why don’t 3M and all the others say you can use ISO paints with their half masks? It looks like they just don’t want the liability, because with disposable filters the only way you know it’s not working is if you smell the paint, at which time you’ve already inhaled those isocyanates.
To avoid that problem you just need to keep track of how long you’ve used the filters, and replace them before the specified usage time has elapsed. For example if the filters say that they last 20 hours of normal use, just change it after a day (8-10hrs or something) and you’ll be fine. Both the prefilter (for the actual paint/particles) and the organic vapor filter (for chemical stuff, ISO’s etc.) will need to be changed. (Of course be sure that you have the right kinds of filters. The particle filter should be easy, but I believe there are different grades of organic vapor filters.)
If you’re using filter based respirators, don’t paint in a closed room. It may seem like a good idea to keep dust out (and stop the paint/fumes/etc. from getting out) but that’s going to use up your filters much faster and you could probably easily overdo it and inhale some fumes. Not to mention that it would create a fairly explosive environment with all those fumes collecting…
It’s also worth noting that some areas have an outright ban on spraying isocyanates, check with your local council etc. etc. Also if you choose to spray in your home shed, be aware of anyone else who is around, for example the neighbour kids playing in the yard, the elderly lady working in her garden etc… they will not be protected if any paint/vapours reach them… (But these are entirely different issues to the safety equipment required.)