The latex is pressed against the (wooden) frame by drywall screws passing through the top Lexan sheet and piercing the latex. The latex becomes it’s own gasket…
You project cost seem sky-high to me. Why use metal? You can easily do a very stable laminated base from moisture-resistant MDF, topped by 1/8" acrylic. That would cost $25. The frame (mine) is also laminated MDF, and the latex costs $50. The big square of Lexan, I realized later, is not necessary. I could have used narrow sections of it that only covered the frame and sealed the latex. In my shop the whole work table is the vacuum table base, with one vacuum port in it. Then, I have multiple “clamps” of different depths and sizes to suit my different needs.
The most popular of composite guitars is what called a “double-top”. Some go for as much as $35,000. The typical recipe for the soundboard of a composite guitar is two skins of 0.6 mm spruce or cedar that sandwich a varying-thickness nomex honeycomb core, bonded together with epoxy or polyurethane glue. The weight is reduced by as much as 50 %, making the soundboard much easier to activate. Unfortunately, the drastic change in weight also changes the frequency response drastically, and many sound very “untraditional” to the discerning ear.