Depends what kind of failure.
In my understanding, the low pressure scenario is not a primary cause of failure as long as the structure; it is the cyclical nature of high pressure, low pressure, etc experienced by aircraft going up and down that will cause, for example, porosity to initiate a crack or just to grow an existing crack. However, if there is air trapped within the honeycomb during manufacturing for example, where the air hasn’t been evacuated properly, then there will obviously be a considerable pressure differential between the internal pressure in the honeycomb and the external high altitude environment. Therefore, this can also cause internal stresses and initiate a crack around an air bubble for example. Is combatting thei problem what you mean when you talk of ventilized honeycomb? You can of course use a spiked roller for example during lay-up to assist with air removal from the honeycomb during manufacture